Current insights into matrix metalloproteinases and glioma progression: transcending the degradation boundary
نویسندگان
چکیده
منابع مشابه
New insights into the world of matrix metalloproteinases.
The article by Carrel et al 1 in the present issue of Circulation provides remarkable new insights into the matrix metalloproteinases (MMPs) and their effects on the remodeling of the vascular system in aortic atherosclerotic and aneurysmal lesions. The MMPs constitute a family of endopeptidases that have in common the presence of zinc in their active site, a dependency on Ca for their activity...
متن کاملNew Insights into the Role of Matrix Metalloproteinases in Preeclampsia
Preeclampsia is a severe pregnancy complication globally, characterized by poor placentation triggering vascular dysfunction. Matrix metalloproteinases (MMPs) exhibit proteolytic activity implicated in the efficiency of trophoblast invasion to the uterine wall, and a dysregulation of these enzymes has been linked to preeclampsia. A decrease in MMP-2 and MMP-9 interferes with the normal remodeli...
متن کاملMatrix Metalloproteinases, New Insights into the Understanding of Neurodegenerative Disorders
Matrix metalloproteinases (MMPs) are a subfamily of zinc-dependent proteases that are responsible for degradation and remodeling of extracellular matrix proteins. The activity of MMPs is tightly regulated at several levels including cleavage of prodomain, allosteric activation, compartmentalization and complex formation with tissue inhibitor of metalloproteinases (TIMPs). In the central nervous...
متن کاملThe role of matrix metalloproteinases in glioma invasion.
The matrix metalloproteinase (MMP) family plays an important role in the degradation of extracellular matrix (ECM) in various physiological and pathological conditions. Accumulated evidence has suggested that MMPs contribute to cancer cell invasion of the surrounding normal tissues and metastasis through the cell-surface ECM degradation. Strong correlations have been reported between elevated M...
متن کاملExtracellular Matrix Microenvironment in Glioma Progression
Malignant gliomas are primary brain tumors, which are highly invasive but not known to metastasize outside the central nervous system (CNS). The median survival time of patients with glioma is only 6 months to 2 years depending on various patient, tumor and treatment parameters (Louis et al. 2007). The highly aggressive character of gliomas with glioblastoma multiforme (GBM) being the most aggr...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Metalloproteinases In Medicine
سال: 2018
ISSN: 2324-2027
DOI: 10.2147/mnm.s105123